Gardnerella vaginalis alters cervicovaginal epithelial cell function through microbe-specific immune responses.

ABSTRACT:

Background

The cervicovaginal (CV) microbiome is highly associated with vaginal health and disease in both pregnant and nonpregnant individuals. An overabundance of Gardnerella vaginalis (G. vaginalis) in the CV space is commonly associated with adverse reproductive outcomes including bacterial vaginosis (BV), sexually transmitted diseases, and preterm birth, while the presence of Lactobacillus spp. is often associated with reproductive health. While host-microbial interactions are hypothesized to contribute to CV health and disease, the mechanisms by which these interactions regulate CV epithelial function remain largely unknown.

Results

Using an in vitro co-culture model, we assessed the effects of Lactobacillus crispatus (L. crispatus) and G. vaginalis on the CV epithelia

SUBMITTER: Anton L 

PROVIDER: S-EPMC9351251 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature