Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study.

ABSTRACT:

Objectives

Studies suggest that body composition can be independently improved through physical activity (PA). We performed a Mendelian randomisation (MR) study to test the incremental benefits of sedentary behaviour and various PA exposures on body composition outcomes as assessed by anthropometric indices, lean body mass (kg), body fat (%) and visceral adipose tissue (VAT) (kg).

Methods

Genetic instruments were identified for both self-reported and accelerometer-measured sedentary behaviour and PA. Outcomes included anthropometric and dual-energy X-ray absorptiometry measures of adiposity, extracted from the UK Biobank and the largest available consortia. Multivariable MR (MVMR) included educational attainment as a covariate to address potential confounding. Sensiti

SUBMITTER: Ramadan FA 

PROVIDER: S-EPMC9351346 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature