Adsorption free energy predicts amyloid protein nucleation rates.

ABSTRACT: Primary nucleation is the fundamental event that initiates the conversion of proteins from their normal physiological forms into pathological amyloid aggregates associated with the onset and development of disorders including systemic amyloidosis, as well as the neurodegenerative conditions Alzheimer's and Parkinson's diseases. It has become apparent that the presence of surfaces can dramatically modulate nucleation. However, the underlying physicochemical parameters governing this process have been challenging to elucidate, with interfaces in some cases having been found to accelerate aggregation, while in others they can inhibit the kinetics of this process. Here we show through kinetic analysis that for three different fibril-forming proteins, interfaces affect the aggregation reaction

SUBMITTER: Toprakcioglu Z 

PROVIDER: S-EPMC9351353 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature