Transcription factor EB coordinates environmental cues to regulate T regulatory cells' mitochondrial fitness and function.

ABSTRACT: T regulatory (Treg) cells are essential for self-tolerance whereas they are detrimental for dampening the host anti-tumor immunity. How Treg cells adapt to environmental signals to orchestrate their homeostasis and functions remains poorly understood. Here, we identified that transcription factor EB (TFEB) is induced by host nutrition deprivation or interleukin (IL)-2 in CD4⁺ T cells. The loss of TFEB in Treg cells leads to reduced Treg accumulation and impaired Treg function in mouse models of cancer and autoimmune disease. TFEB intrinsically regulates genes involved in Treg cell differentiation and mitochondria function while it suppresses expression of proinflammatory cytokines independently of its established roles in autophagy. This coordinated action is required for mitoch

SUBMITTER: Xia M 

PROVIDER: S-EPMC9351480 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature