MiRNA-based "fitness score" to assess the individual response to diet, metabolism, and exercise.

ABSTRACT:

Background

Regular, especially sustained exercise plays an important role in the prevention and treatment of multiple chronic diseases. Some of the underlying molecular and cellular mechanisms behind the adaptive response to physical activity are still unclear, but recent findings suggest a possible role of epigenetic mechanisms, especially miRNAs, in the progression and management of exercise-related changes. Due to the combination of the analysis of epigenetic biomarkers (miRNAs), the intake of food and supplements, and genetic dispositions, a "fitness score" was evaluated to assess the individual response to nutrition, exercise, and metabolic influence.

Methods

In response to a 12-week sports intervention, we analyzed genetic and epigenetic biomarkers in capillary blood f

SUBMITTER: Krammer UDB 

PROVIDER: S-EPMC9351578 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature