Modeling spatial interaction networks of the gut microbiota.

ABSTRACT: How the gut microbiota is organized across space is postulated to influence microbial succession and its mutualistic relationships with the host. The lack of dynamic or perturbed abundance data poses considerable challenges for characterizing the spatial pattern of microbial interactions. We integrate allometric scaling theory, evolutionary game theory, and prey-predator theory into a unified framework under which quasi-dynamic microbial networks can be inferred from static abundance data. We illustrate that such networks can capture the full properties of microbial interactions, including causality, the sign of the causality, strength, and feedback loop, and are dynamically adaptive along spatial gradients, and context-specific, characterizing variability between individuals and within th

SUBMITTER: Cao X 

PROVIDER: S-EPMC9351588 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature