Reduction of Laser-Induced Choroidal Neovascularization in Mice With Erythropoietin RNA Interference.

ABSTRACT:

Purpose

The purpose of this study was to evaluate the pathological involvement of erythropoietin (EPO) in experimental choroidal neovascularization (CNV) and its association with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) in the Chinese population.

Methods

Treatment effect of recombinant EPO protein were assessed by human umbilical vein endothelial cell (HUVEC) proliferation, migration, and tube formation, and ex vivo choroid-sprouting ability. The effect of intravitreal injection of Epo siRNA against neovascularization was evaluated in the laser-induced CNV mouse model. In addition, the association of EPO variants with neovascular AMD and PCV was determined.

Results

Exogenous supplementation of EPO significantly enh

SUBMITTER: Lv W 

PROVIDER: S-EPMC9351596 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature