Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ_1-42 Mice via α7nAChR-Dependent BDNF Upregulation.

ABSTRACT: Alzheimer's disease (AD) is characterized pathologically by the structural and functional impairments of synapses in the hippocampus, inducing the learning and memory deficiencies. Ras GTPase is closely related to the synaptic function and memory. This study was to investigate the effects of farnesyl transferase inhibitor lonafarnib on the synaptic structure and function in AD male mice and explore the potential mechanism. Our results showed 50 mg/kg lonafarnib (intraperitoneal) rescued the impaired spatial memory and improved the damaged synaptic transmission and plasticity of Aβ_1-42 mice. In addition, lonafarnib ameliorated the morphology of synaptic dendrites and spines in Aβ_1-42 mice. Furthermore, lonafarnib enhanced α7nAChR cell surface expression and phosphoryla

SUBMITTER: Cai C 

PROVIDER: S-EPMC9351638 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature