Catecholamines in neuroblastoma: Driver of hypertension, or solely a marker of disease?

ABSTRACT:

Background

Neuroblastoma is a common solid tumor of childhood and is often associated with hypertension. Potential etiologies contributing to hypertension include renal compression, pain, volume overload, and catecholamine secretion.

Cases

We completed a single center retrospective review of children with neuroblastoma and ≥stage II hypertension (per Hypertension Canada guidelines) over a 2-year period. All patients (n = 10) had elevated urine normetanephrine levels and eight had intra-abdominal tumors. Four patients had refractory hypertension requiring > three agents, of which three required alpha/beta blockade.

Conclusion

Although multifactorial, hypertension in neuroblastoma often has a neuroendocrine component. Excess normetanephrine production in neuroblastoma m

SUBMITTER: Harding M 

PROVIDER: S-EPMC9351666 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature