Association of anti-TNF-α treatment with gut microbiota of patients with ankylosing spondylitis.

ABSTRACT:

Objective

Gut dysbiosis contributes to multiple autoimmune diseases, including ankylosing spondylitis, which is commonly treated with tumor necrosis factor (TNF)-α inhibitors (TNFis). Because host TNF-α levels are considered to interact with gut microbiota, we aimed to systematically investigate the microbiota profile of ankylosing spondylitis patients with anti-TNF-α-based treatment and identify potential key bacteria.

Methods

Fecal samples were collected from 11 healthy controls and 24 ankylosing spondylitis patients before/after anti-TNF-α treatment, the microbiota profiles of which were evaluated by 16S ribosomal DNA amplicon sequencing and subsequent bioinformatic analysis.

Results

Significantly different microbial compositions were observed in samples from ankyl

SUBMITTER: Dai Q 

PROVIDER: S-EPMC9351697 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature