Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination.

ABSTRACT: B lymphocytes develop from uncommitted precursors into immunoglobulin (antibody)-producing B cells, a major arm of adaptive immunity. Progression of early progenitors to antibody-expressing cells in the bone marrow is orchestrated by the temporal regulation of different gene programs at discrete developmental stages. A major question concerns how B cells control the accessibility of these genes to transcription factors. Research has implicated nucleosome remodeling ATPases as mediators of chromatin accessibility. Here, we describe studies of chromodomain helicase DNA-binding 4 (CHD4; also known as Mi-2β) in early B cell development. CHD4 comprises multiple domains that function in nucleosome mobilization and histone binding. CHD4 is a key component of Nucleosome Remodeling and Deacetylase,

SUBMITTER: Hagman JR 

PROVIDER: S-EPMC9351717 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature