Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition.

ABSTRACT: Balloon angioplasty followed by local delivery of antiproliferative drugs to target tissue is increasingly being considered for the treatment of obstructive arterial disease, and yet there is much to appreciate regarding pharmacokinetics in arteries of non-uniform disease. We developed a computational model capable of simulating drug-coated balloon delivery to arteries of heterogeneous tissue composition comprising healthy tissue, as well as regions of fibrous, fibro-fatty, calcified and necrotic core lesions. Image processing using an unsupervised clustering technique was used to reconstruct an arterial geometry from a single, patient-specific color image obtained from intravascular ultrasound-derived virtual histology. Transport of free drug was modeled using a time-dependent reaction-di

SUBMITTER: Mandal PK 

PROVIDER: S-EPMC9351813 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature