A novel ferroptosis-related long noncoding RNA signature for relapse free survival prediction in patients with breast cancer.

ABSTRACT: Ferroptosis is the process of cell death dependent on iron. Growing evidence suggests that ferroptosis plays vital roles in the biological process of many cancers. However, just a small number of ferroptosis-related lncRNAs have been explored in depth. Ferroptosis-related lncRNAs in breast cancer (BC) were identified by co-expression analysis based on The Cancer Genome Atlas database (TCGA). The whole set was divided into a training set and a test set with a 1:1 ratio. Univariate Cox regression and LASSO analyses were performed to establish a signature in the 3 sets. Kaplan-Meier analysis and receiver operating characteristic (ROC) for the 3 sets validated the effectiveness and robustness of the signature. Besides, we also explore the relationship between this and clinical characteristics,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9351903 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature