Markers of Systemic Inflammation in Acute Attacks of Ulcerative Colitis: What Level of C-reactive Protein Constitutes Severe Colitis?

ABSTRACT:

Background and aims

The erythrocyte sedimentation rate [ESR] as a component of the Truelove and Witts Criteria [TWC] is the traditional inflammatory marker used for the assessment of ulcerative colitis [UC] activity. However, the C-reactive protein [CRP] is preferentially used in contemporary clinical practice. We aimed to determine the equivalent CRP cut-off for an ESR of  >30 mm/h in patients presenting with acute severe UC.

Methods

Clinical and pathological data were prospectively collected from 163 presentations of severe UC. A CRP cut-off corresponding to an ESR of  >30 mm/h was determined using confusion matrices. A validation cohort of 128 presentations was prospectively collected and analysed.

Results

A CRP cut-off of ≥12 mg/L generated an 85% positive predict

SUBMITTER: Croft A 

PROVIDER: S-EPMC9351978 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature