Characterization of social behavior in young and middle-aged ChAT-IRES-Cre mouse.

ABSTRACT: The cholinergic system is an important modulator of brain processes. It contributes to the regulation of several cognitive functions and emotional states, hence altering behaviors. Previous works showed that cholinergic (nicotinic) receptors of the prefrontal cortex are needed for adapted social behaviors. However, these data were obtained in mutant mice that also present alterations of several neurotransmitter systems, in addition to the cholinergic system. ChAT-IRES-Cre mice, that express the Cre recombinase specifically in cholinergic neurons, are useful tools to investigate the role of the cholinergic circuits in behavior. However, their own behavioral phenotype has not yet been fully characterized, in particular social behavior. In addition, the consequences of aging on the cholinergi

SUBMITTER: Lhopitallier C 

PROVIDER: S-EPMC9352053 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature