Glycated haemoglobin and fasting plasma glucose tests in the screening of outpatients for diabetes and abnormal glucose regulation in Uganda: A diagnostic accuracy study.

ABSTRACT:

Background and objectives

To understand the utility of glycated haemoglobin (HBA1C) in screening for diabetes and Abnormal Glucose Regulation (AGR) in primary care, we compared its performance to that of the fasting plasma glucose (FPG) test.

Methods

This was a prospective diagnostic accuracy study conducted in eastern Uganda. Patients eligible for inclusion were consecutive adults, 30-75 years, receiving care at the outpatient department of a general hospital in eastern Uganda. We determined the sensitivity, specificity and optimum cut-off points for HBA1C and FPG tests using the oral glucose tolerance test (OGTT) as a clinical reference standard.

Results

A total of 1659 participants underwent FPG testing of whom 310 were also HBA1C and OGTT tested. A total of 113 te

SUBMITTER: Kasujja FX 

PROVIDER: S-EPMC9352087 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature