Heterodinuclear Ru-Pt Complexes Bridged with 2,3-Bis(pyridyl)pyrazinyl Ligands: Studies on Kinetics, Deoxyribonucleic Acid/Bovine Serum Albumin Binding and Cleavage, In Vitro Cytotoxicity, and In Vivo Toxicity on Zebrafish Embryo Activities.

ABSTRACT: Di- and poly-homo/heteronuclear complexes have great potential as anticancer drugs. Here, we report their reactivity, deoxyribonucleic acid (DNA)/bovine serum albumin (BSA) binding and cleavage interactions, in vitro cytotoxicity, and in vivo zebrafish embryo toxicity of [(phen)₂Ru(μ-L)PtCl₂]²⁺ (phen = 1,10-phenanthroline and L = 2,3-bis(2-pyridyl)pyrazine, bpp, C₁ ; 2,3-bis(2-pyridyl)quinoxaline, bpq, C_2ial ; 2,3-bis(2-pyridyl)benzo[g]quinoxaline, bbq, C₃ ) anticancer prodrugs. The substitution reactivity increases from C₁ to C₃ owing to an increase in the π-conjugation on the bridging chelate which facilitates π-back bonding. As a result, the ele

SUBMITTER: Bellam R 

PROVIDER: S-EPMC9352169 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature