New Chitosan-Grafted Thymol Coated on Gold Nanoparticles for Control of Cariogenic Bacteria in the Oral Cavity.

ABSTRACT: Chitosan-grafted thymol (CST) coated on gold nanoparticles has been synthesized and characterized for the design of antimicrobial materials. CST was synthesized via adapting the Mannich reaction, and it acted as the capping agent for the synthesis of gold nanoparticles (AuNPs). The grafting of thymol onto the side chain of chitosan has provided a degree of substitution value (%DS_NMR) of 10.0%, calculated by nuclear magnetic resonance spectroscopy. UV-visible spectrometry and elemental analysis were used to confirm the successful synthesis of CST through adapting the Mannich reaction. The appropriate concentration of CST for AuNP synthesis was found to be 0.020%w/v. A red-wine colloidal AuNP solution of 2.41-3.30 nM particle size exhibits a strong surface plasmon resonance at 502

SUBMITTER: Chittratan P 

PROVIDER: S-EPMC9352254 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature