Effect of Surface Hydrophobicity on the Adsorption of a Pilus-Derived Adhesin-like Peptide.

ABSTRACT: Bacterial colonization of abiotic surfaces such as those of medical implants, membrane filters, and everyday household items is a process of tremendous importance for public health. Bacteria use adhesive cell surface structures called adhesins to establish contact with abiotic surfaces. Among them, protein filaments called type IV pili are particularly important and found in many Gram-negative pathogens such as Pseudomonas aeruginosa. Understanding the interaction of such adhesin proteins with different abiotic surfaces at the molecular level thus represents a fundamental prerequisite for impeding bacterial colonization and preventing the spread of infectious diseases. In this work, we investigate the interaction of a synthetic adhesin-like peptide, PAK128-144ox, derived from the ty

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9352356 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature