Haptoglobin polymorphism affects its N-glycosylation pattern in serum.

ABSTRACT:

Introduction

Haptoglobin (Hp) is an abundant acute-phase protein secreted mainly by the liver into the bloodstream. There are three Hp protein phenotypes (Hp type 1-1, 2-1, and 2-2), which differ in the number of α- and β-chains, type of α-chain (the β-chain type remains the same in all the Hp phenotypes), and the polymers that they form via disulfide bonds. Hp has four N-glycosylation sites on the β-chain. Glycosylation of Hp has been reported frequently as a potential glycobiomarker for many diseases; however, whether Hp polymorphism affects its glycosylation has not yet been addressed extensively or in depth.

Objectives

This study investigated the differences between the glycosylation patterns of Hp phenotypes using serum from 12 healthy individuals (four for each Hp phen

SUBMITTER: Kohansal-Nodehi M 

PROVIDER: S-EPMC9352458 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature