Dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD) for diagnosis of osteoporosis - experimental data from artificial vertebrae confirms significant dependence on bone size.

ABSTRACT:

Introduction

The WHO definition of osteoporosis, and published BMD (Bone Mineral Density) references ranges, do not consider differences in bone size. Because it is a two-dimensional technique, and cannot measure bone depth, aBMD (areal BMD) measured using DXA (Dual-energy X-Ray Absorptiometry) is affected by bone size variability. Mathematical models have been devised to correct aBMD for bone size, but these are confounded by variations in soft tissue surrounding bone. Confirmation of the actual quantitative effect on clinical results for patients requires precise changes in bone size and mineral density, but studies of humans and animals are limited by the inability to precisely control these in natural bones.

Purpose

The objectives of this experiment were to obtain precis

SUBMITTER: Golding PH 

PROVIDER: S-EPMC9352459 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature