Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker.

ABSTRACT:

Background

Gangliosides act as important roles in tumor progression. B4GALNT1 is a key enzyme in ganglioside biosynthesis. B4GALNT1 expression is linked to tumorigenesis and the prognosis of tumor patients. Nevertheless, the role of B4GALNT1 in pan-cancer remains unclear.

Methods

Several databases, including TCGA, GEO, GTEx, NCI-60, and TIMER, were searched. Methods including correlation analysis, Cox regression analysis, and Kaplan-Meier analysis were used to explore the expression pattern, prognosis, tumor infiltration pattern, genetics and epigenetics, and drug sensitivity of B4GALNT1 in pan-cancer patients from the above datasets.

Results

B4GALNT1 was found to be aberrantly expressed in multiple types of tumors. The survival status of tumor patients was significan

SUBMITTER: Yi H 

PROVIDER: S-EPMC9352475 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature