Comprehensive Bioinformatics Analysis of Toll-Like Receptors (TLRs) in Pan-Cancer.

ABSTRACT:

Background

To conduct a comprehensive bioinformatics analysis on the transcriptome signatures of Toll-like receptors (TLRs) in pan-cancer. Materials and methods. A total of 11,057 tissues consisting of 33 types of carcinoma in The Cancer Genome Atlas (TCGA) were retrieved, and then we further explored the correlation between TLRs' expression with tumorigenesis, immune infiltration, and drug sensitivity. We conducted a comprehensive bioinformatics analysis on TLR1 to 10 in pan-cancer, including differential expression analysis between normal and tumor tissues, differential immune subtype correlation, survival analysis, tumor immune infiltration estimating, stemness indices correlation, and drug responses correlation.

Results

TLR2 was highly expressed in most types of t

SUBMITTER: Ping W 

PROVIDER: S-EPMC9352480 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature