Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes.

ABSTRACT: Ag-specific tolerizing immunotherapy is considered the optimal strategy to control type 1 diabetes, a childhood disease involving autoimmunity toward multiple islet antigenic peptides. To understand whether tolerizing immunotherapy with a single peptide could control diabetes driven by multiple Ags, we coencapsulated the high-affinity CD4⁺ mimotope (BDC2.5_mim) of islet autoantigen chromogranin A (ChgA) with or without calcitriol (1α,25-dihydroxyvitamin D3) into liposomes. After liposome administration, we followed the endogenous ChgA-specific immune response with specific tetramers. Liposome administration s.c., but not i.v., induced ChgA-specific Foxp3⁺ and Foxp3^- PD1⁺ CD73⁺ ICOS⁺ IL-10⁺ peripheral reg

SUBMITTER: Bergot AS 

PROVIDER: S-EPMC9352518 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature