Effects of 1α,25-dihydroxyvitamin D₃ and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells.

ABSTRACT: The active hormonal form of vitamin D, 1α,25-dihydroxyvitamin D₃, is reported to have 1000s of biological targets. The growth-suppressive properties of 1α,25-dihydroxyvitamin D₃ and its synthetic analogs have attracted interest for the development of treatment and/or prevention of cancer. We examined effects of 1α,25-dihydroxyvitamin D₃ and the vitamin D analog tacalcitol on signaling pathways and anchorage-independent growth in T98G and U251 glioblastoma cells. Assay of signaling proteins important for cellular growth indicated suppression of p70-S6 kinase levels by 1α,25-dihydroxyvitamin D₃ and tacalcitol in T98G cells, whereas the levels of PLCγ, a target for phospholipid signaling, was slightly increased. Activation of STAT3, an important reg

SUBMITTER: Olsson F 

PROVIDER: S-EPMC9352528 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature