Characterizing intrinsic molecular features of the immune subtypes of salivary mucoepidermoid carcinoma.

ABSTRACT:

Introduction

Characterizing the tumor microenvironment (TME) and immune landscape of cancer has been a promising step towards discovering new therapeutic biomarkers and guiding precision medicine; however, its application in mucoepidermoid carcinoma (MEC) has been sparse. Here, we conducted a comprehensive study to understand the properties of the TME and immune profiles of MEC.

Method

20 patients with MEC were collected from Yonsei Head and Neck Cancer Centre, Yonsei University, South Korea. Total RNA sequencing was conducted to determine gene expression profiles. Bioinformatic and immunoinformatic analyses were applied to characterize the TME and identify immunophenotypic subgroups, and to investigate the molecular features that explain the distinct phenotypes.

Results<

SUBMITTER: Kang H 

PROVIDER: S-EPMC9352547 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature