Safety and tolerability of high-dose daily vitamin D₃ supplementation in the vitamin D and type 2 diabetes (D2d) study-a randomized trial in persons with prediabetes.

ABSTRACT:

Background/objectives

Routine use of vitamin D supplements has increased substantially in the United States. However, the safety and tolerability of long-term use of high-dose vitamin D are not known. We assessed the safety and tolerability of high-dose, daily vitamin D₃ in the vitamin D and type 2 diabetes (D2d) study.

Subjects/methods

In total, 2423 overweight/obese persons with prediabetes were randomized in a double-blind manner to either 4000 IU of vitamin D₃ (the tolerable upper intake level for adults by the National Academy of Medicine) taken daily or matching placebo. All participants were included in this analysis. Incident adverse events (AE) were ascertained 4 times a year at in-person visits (twice a year) and interim remote encounters (twi

SUBMITTER: Johnson KC 

PROVIDER: S-EPMC9352576 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature