Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale.

ABSTRACT: The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map brain activity at millimeter resolutions, the recording of functional responses at microscopic scale in mammals remains the privilege of invasive electrophysiological or optical approaches, but is mostly restricted to either the cortical surface or the vicinity of implanted sensors. Ultrasound localization microscopy (ULM) has achieved transcranial imaging of cerebrovascular flow, up to micrometre scales, by localizing intravenously injected microbubbles; however, the long acquisition time required to detect microbubbles within microscopic vessels has so far restricted ULM application mainly to microvasculature structural im

SUBMITTER: Renaudin N 

PROVIDER: S-EPMC9352591 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature