Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes.

ABSTRACT: Classical HLA (Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA genes and disease association has been studied at least since 1967 and no firm pathogenic mechanisms have been established yet. HLA-G immune modulation gene (and also -E and -F) are starting the same arduous way: statistics and allele association are the trending subjects with the same few results obtained by HLA classical genes, i.e., no pathogenesis may be discovered after many years of a great amount of researchers' effort. Thus, we believe that it is necessary to follow different research methodologies: (1) to approach this problem, based on how evolution has worked maintaining together a cluster of immune-related genes (the MHC) in a relatively short chromosome area since amniotes to huma

SUBMITTER: Arnaiz-Villena A 

PROVIDER: S-EPMC9352621 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature