Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings.

ABSTRACT: Immunocompromised patients are predisposed to severe COVID-19. Here we compare homotypic and heterotypic humoral and cellular immune responses to Omicron BA.1 in organ transplant patients across a diverse clinical spectrum. We perform variant-specific pseudovirus neutralization assays for D614G, and Omicron-BA.1, -BA.2, and Delta variants. We also measure poly-and monofunctional T-cell responses to BA.1 and ancestral SARS-CoV-2 peptide pools. We identify that partially or fully-vaccinated transplant recipients after infection with Omicron BA.1 have the greatest BA.1 neutralizing antibody and BA.1-specific polyfunctional CD4⁺ and CD8⁺ T-cell responses, with potent cross-neutralization against BA.2. In these patients, the magnitude of the BA.1-directed response is compa

SUBMITTER: Ferreira VH 

PROVIDER: S-EPMC9352686 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature