Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound.

ABSTRACT: Transcranial focused ultrasound with the InSightec Exablate system uses thermal ablation for the treatment of movement and mood disorders and blood brain barrier disruption for tumor therapy. The system uses computed tomography (CT) images to calculate phase corrections that account for aberrations caused by the human skull. This work investigates whether magnetic resonance (MR) images can be used as an alternative to CT images to calculate phase corrections. Phase corrections were calculated using the gold standard hydrophone method and the standard of care InSightec ray tracing method. MR binary image mask, MR-simulated-CT (MRsimCT), and CT images of three ex vivo human skulls were supplied as inputs to the InSightec ray tracing method. The degassed ex vivo human skulls were sonicated wi

SUBMITTER: Leung SA 

PROVIDER: S-EPMC9352781 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature