Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans.

ABSTRACT: Adjuvants can alter the magnitude, characteristics, and persistence of the humoral response to protein vaccination. HIV vaccination might benefit from tailored adjuvant choice as raising a durable and protective response to vaccination has been exceptionally challenging. Analysis of trials of partially effective HIV vaccines have identified features of the immune response that correlate with decreased risk, including high titers of V1V2-binding IgG and IgG3 responses with low titers of V1V2-binding IgA responses and enhanced Fc effector functions, notably antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). However, there has been limited opportunity to compare the effect of different adjuvants on these activities in humans. Here, samples fro

SUBMITTER: Xu S 

PROVIDER: S-EPMC9352797 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature