Quantitative SPECT/CT imaging of lead-212: a phantom study.

ABSTRACT:

Background

Lead-212 (²¹²Pb) is a promising radionuclide for targeted therapy, as it decays to α-particle emitter bismuth-212 (²¹²Bi) via β-particle emission. This extends the problematic short half-life of ²¹²Bi. In preparation for upcoming clinical trials with ²¹²Pb, the feasibility of quantitative single photon-emission computed tomography/computed tomography (SPECT/CT) imaging of ²¹²Pb was studied, with the purpose to explore the possibility of individualised patient dosimetric estimation.

Results

Both acquisition parameters (combining two different energy windows and two different collimators) and iterative reconstruction parameters (varying the iterations x subsets between 10 × 1, 15 × 1, 30 × 1, 30 × 2, 30 × 3, 30 

SUBMITTER: Kvassheim M 

PROVIDER: S-EPMC9352840 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature