The prognostic implications of SIRTs expression in breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Sirtuins (SIRTs) have key roles in cancer progression. However, the prognostic implications of SIRTs in breast cancer (BC) remains a subject of debate and controversy. Thus, we performed a meta-analysis to identify the precise prognostic value of SIRTs in BC patients.

Methods

Systematic literature searching was conducted in PubMed, Cochrane Library, Web of Science, and Embase databases. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to estimate the association of SIRTs expression and survival outcomes in BC patients.

Results

A total of 22 original studies with 6317 patients were eligible for this meta-analysis. The results showed that in patients with BC, elevated SIRTs levels were associated with shorter overall survival

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9352848 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature