NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation.

ABSTRACT: In vitro maturation (IVM) refers to the process of developing immature oocytes into the mature in vitro under the microenvironment analogous to follicle fluid. It is an important technique for patients with polycystic ovary syndrome and, especially, those young patients with the need of fertility preservation. However, as the mechanisms of oocyte maturation have not been fully understood yet, the cultivation efficiency of IVM is not satisfactory. It was confirmed in our previous study that oocyte maturation was impaired after N-acetyltransferase 10 (NAT10) knockdown (KD). In the present study, we further explored the transcriptome alteration of NAT10-depleted oocytes and found that O-GlcNAcase(OGA) was an important target gene for NAT10-mediated ac4C modificatio

SUBMITTER: Lin J 

PROVIDER: S-EPMC9352860 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature