Early detection of ureteropelvic junction obstruction in neonates with prenatal diagnosis of renal pelvis dilatation using ¹H NMR urinary metabolomics.

ABSTRACT: Renal pelvis dilatation (RPD) is diagnosed in utero on prenatal ultrasonography (US) and can resolve spontaneously. However, isolated RPD can also reflect ureteropelvic junction obstruction (UPJO), which requires surgical treatment to prevent progressive renal deterioration. The diagnosis of UPJO can only be confirmed after birth with repeat US and renal isotope studies. ¹H Nuclear Magnetic Resonance spectroscopy (NMR) was performed on urine of newborns with prenatally diagnosed unilateral RPD and healthy controls to identify specific urinary biomarkers for UPJO. The original combination of EigenMS normalization and sparse partial-least-squares discriminant analysis improved selectivity and sensitivity. In total, 140 urine samples from newborns were processed and 100 metabolites

SUBMITTER: Scalabre A 

PROVIDER: S-EPMC9352869 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature