Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor.

ABSTRACT: Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified. Recent advances in pharmacogenomics have previously been useful to identify disease related molecular targets. Notably, gene expression has proven to be quite successful for the inference of drug response in cell models. We sought to leverage this approach in the context of ET where many patients are responsive to two drugs: propranolol and primidone. In this study, cerebellar DAOY and neural progenitor cells were treated for 5 days with clinical concentrations of propranolol and primidone, after which RNA-sequencing was used to identify convergent differentially expressed genes across treatments. Proprano

SUBMITTER: Castonguay CE 

PROVIDER: S-EPMC9352876 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature