Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer.

ABSTRACT: Various omics-based biomarkers related to the occurrence, progression, and prognosis of colorectal cancer (CRC) have been identified. In this study, we attempted to identify gut microbiome-based biomarkers and detect their association with host gene expression in the initiation and progression of CRC by integrating analysis of the gut mucosal metagenome, RNA sequencing, and sociomedical factors. We performed metagenome and RNA sequencing on colonic mucosa samples from 13 patients with advanced CRC (ACRC), 10 patients with high-risk adenoma (HRA), and 7 normal control (NC) individuals. All participants completed a questionnaire on sociomedical factors. The interaction and correlation between changes in the microbiome and gene expression were assessed using bioinformatic analysis. When compa

SUBMITTER: Kim N 

PROVIDER: S-EPMC9352898 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature