Voltage-Gated Ion Channels and the Variability in Information Transfer.

ABSTRACT: The prerequisites for neurons to function within a circuit and be able to contain and transfer information efficiently and reliably are that they need to be homeostatically stable and fire within a reasonable range, characteristics that are governed, among others, by voltage-gated ion channels (VGICs). Nonetheless, neurons entail large variability in the expression levels of VGICs and their corresponding intrinsic properties, but the role of this variability in information transfer is not fully known. In this study, we aimed to investigate how this variability of VGICs affects information transfer. For this, we used a previously derived population of neuronal model neurons, each with the variable expression of five types of VGICs, fast Na⁺, delayed rectifier K⁺, A-typ

SUBMITTER: Rathour RK 

PROVIDER: S-EPMC9352938 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature