Common Core Genes Play Vital Roles in Gastric Cancer With Different Stages.

ABSTRACT: Background : Owing to complex molecular mechanisms in gastric cancer (GC) oncogenesis and progression, existing biomarkers and therapeutic targets could not significantly improve diagnosis and prognosis. This study aims to identify the key genes and signaling pathways related to GC oncogenesis and progression using bioinformatics and meta-analysis methods. Methods: Eligible microarray datasets were downloaded and integrated using the meta-analysis method. According to the tumor stage, GC gene chips were classified into three groups. Thereafter, the three groups' differentially expressed genes (DEGs) were identified by comparing the gene data of the tumor groups with those of matched normal specimens. Enrichment analyses were conducted based on common DEGs among the thr

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9352954 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature