De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients.

ABSTRACT:

Background

The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with decreased susceptibility to neutralizing antibodies is of clinical importance. Several spike mutations associated with immune escape have evolved independently in association with different variants of concern (VOCs). How and when these mutations arise is still unclear. We hypothesized that such mutations might arise in the context of persistent viral replication in immunosuppressed hosts.

Methods

Nasopharyngeal specimens were collected longitudinally from two immunosuppressed patients with persistent SARS-CoV-2 infection. Plasma was collected from these same patients late in disease course. SARS-CoV-2 whole genome sequencing was performed to assess the emergence

SUBMITTER: Simons LM 

PROVIDER: S-EPMC9353292 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature