Pan-cancer analysis of the FAM83 family and its association with prognosis and tumor microenvironment.

ABSTRACT: Family with sequence similarity 83 (FAM83) is a newly identified family of oncogenes whose members play important roles in signaling and cancer progression. However, a thorough understanding of the FAM83 family in tumors is still lacking. Here, we performed a comprehensive analysis of the expression levels of the FAM83 family across cancers and patient prognoses using bioinformatics methods. We found that the expression levels of FAM83 family genes were upregulated in most tumors, and importantly, high expression levels of FAM83 family genes were related to poor prognosis in most tumors. In addition, we analyzed the relationship of FAM83 family genes with immune subtypes and the tumor microenvironment (TME). The results showed that FAM83 family genes were significantly associated with immu

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9353330 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature