Urinary matrix Gla protein is associated with mortality risk in Flemish population: A prospective study.

ABSTRACT:

Background

Vascular calcification is strongly related to the risk of mortality and cardiovascular (CV) diseases. In vascular calcification, matrix Gla protein (MGP), a small vitamin K-dependent protein, is an important mineralization inhibitor. Recent studies showed that circulating MGP is associated with mortality risk. However, the longitudinal association between urinary excretion of MGP and all-cause mortality was not established.

Materials and methods

Urinary MGP was measured in 776 randomly recruited Flemish population (mean age: 51.2 years; 50.9% women) at baseline (during 2005-2010) using capillary electrophoresis coupled with mass spectrometry. Plasma inactive MGP [desphospho-uncarboxylated MGP (dp-ucMGP)] levels were quantified in 646 individuals by ELISA kits. Mor

SUBMITTER: Wei D 

PROVIDER: S-EPMC9353515 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature