Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus.

ABSTRACT: The larynx, trachea, and esophagus share origin and proximity during embryonic development. Clinical and experimental evidence support the existence of neurophysiological, structural, and functional interdependencies before birth. This investigation provides the first comprehensive transcriptional profile of all three organs during embryonic organogenesis, where differential gene expression gradually assembles the identity and complexity of these proximal organs from a shared origin in the anterior foregut. By applying bulk RNA sequencing and gene network analysis of differentially expressed genes (DEGs) within and across developing embryonic mouse larynx, esophagus, and trachea, we identified co-expressed modules of genes enriched for key biological processes. Organ-specific temporal patt

SUBMITTER: Wendt KD 

PROVIDER: S-EPMC9353518 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature