Identification of Immune-Related Hub Genes in Parkinson's Disease.

ABSTRACT: Background: Parkinson's disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an essential role in the pathogenic process of PD. The objective of this study was to explore potential immune-related hub genes and immune infiltration patterns of PD. Method: The microarray expression data of human postmortem substantia nigra samples were downloaded from GSE7621, GSE20141, and GSE49036. Key module genes were screened via weighted gene coexpression network analysis, and immune-related genes were intersected to obtain immune-key genes. Functional enrichment analysis was performed on immune-key genes of PD. In addition to, immune infiltration analysis was applied by a single-sample gene set en

SUBMITTER: Chen L 

PROVIDER: S-EPMC9353688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature