Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. However, the number of patients with chronic kidney disease (CKD) is on the rise because of the increase in lifestyle-related diseases.

Aim

To establish a tailored management strategy for HCC patients, we evaluated the impact of comorbid renal dysfunction (RD), as stratified by using the estimated glomerular filtration rate (EGFR), and assessed the oncologic validity of hepatectomy for HCC patients with RD.

Methods

We enrolled 800 HCC patients who underwent hepatectomy between 1997 and 2015 at our university hospital. We categorized patients into two (RD, EGFR < 60 mL/min/1.73 m²; non-RD, EGFR ≥ 60 mL/min/1.73 m²) and three groups (severe CKD, EGFR < 30 mL

SUBMITTER: Sakamoto Y 

PROVIDER: S-EPMC9353748 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature