Contribution of circulatory cells to asthma exacerbations and lung tissue-resident CD4 T cell memory.

ABSTRACT: Tissue-resident memory CD4 T cells (Trm) are thought to be a major contributor to asthma relapse, but the role of circulatory T cells in asthma exacerbations or to maintaining the population of lung Trm cells is not fully understood. Here, we used a house dust mite allergen-based murine model of asthma relapse, and monitored the development of lung effector/Trm phenotype CD44^hiCD62L^loCD69⁺ CD4 T cells. To determine the contribution of circulatory cells, mice were treated with FTY720, to block lymphocyte egress from lymph nodes. Inhibiting the primary migration of circulatory cells to the lungs mitigated the accumulation and expansion of allergen-driven Trm phenotype cells, but subsequent allergen challenges still resulted in strong lung inflammation and Trm

SUBMITTER: Sethi GS 

PROVIDER: S-EPMC9353789 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature