Role of EphB2/ephrin-B1 signalling in the development and progression of obesity-associated colorectal cancer.

ABSTRACT: Obesity is a major problem worldwide and has been associated with colorectal cancer development, among other diseases. Ephrin receptors and ligands play an important role in the turnover of the intestinal mucosa and intestinal crypt compartmentalization. It has been hypothesised that obesity-induced inflammation affects ephrin signals, leading to carcinogenesis. Therefore, the aim of the present study was to assess the relationship between Eph-ephrin B signalling, obesity and obesity-associated colorectal cancer. An azoxymethane-induced obesity-associated cancer KKAy mouse model developed in our prior study was used. A total of 46 patients with consecutive colorectal cancer and 48 tumours were analysed. Immunohistological analyses were performed in mouse and human samples, and immunoreacti

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC9353875 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature