Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression.

ABSTRACT:

Background

Depression is a debilitating mental disorder that often coexists with anxiety. The genetic mechanisms of depression and anxiety have considerable overlap, and studying depression in non-anxiety samples could help to discover novel gene. We assess the genetic variation of depression in non-anxiety samples, using genome-wide association studies (GWAS) and linkage disequilibrium score regression (LDSC).

Methods

The GWAS of depression score and self-reported depression were conducted using the UK Biobank samples, comprising 99,178 non-anxiety participants with anxiety score <5 and 86,503 non-anxiety participants without self-reported anxiety, respectively. Replication analysis was then performed using two large-scale GWAS summary data of depression from Psychiatric Ge

SUBMITTER: Cheng B 

PROVIDER: S-EPMC9353885 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature