Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis.

ABSTRACT: Diabetes increases the occurrence and severity of atherosclerosis. When plaques form in brain vessels, cerebral atherosclerosis causes thickness, rigidity, and unstableness of cerebral artery walls, leading to severe complications like stroke and contributing to cognitive impairment. So far, the molecular mechanism underlying cerebral atherosclerosis is not determined. Moreover, effective intervention strategies are lacking. In this study, we showed that polarization of microglia, the resident macrophage in the central nervous system, appeared to play a critical role in the pathological progression of cerebral atherosclerosis. Microglia likely underwent an M2c-like polarization in an environment long exposed to high glucose. Experimental suppression of microglia M2c polarization was achiev

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9353938 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature